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KMID : 0811820090130010014
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Journal of Korean Society of Pediatric Nephrology
2009 Volume.13 No. 1 p.14 ~ p.20
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Growth Hormone Treatment in Children with Chronic Kidney Disease
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Chung Woo-Yeong
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Abstract
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Growth retardation is a common consequenc of chronic kidney disease (CKD) in childhood. Many recent clinical and experimental data indicate that growth failure in CKD is mainly due to a relative GH insensitivity and functional IGF-I deficiency. Glucocorticoids also glucocorticoids interfere with the integrity of the somatotropic hormone axis at various levels. Over the past 10 years, recombinant growth hormone (rhGH) has been used to help short children with chronic kidney disease. A GH dosage of 0.35 mg/kg/week (28 IU/m2/week) appears efficient and safe. Some clinical trial data show that final height will be within the normal target height range when GH treatment is continued for many years without remarkable adverse events.
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KEYWORD
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Chronic kidney disease, Children, GH/IGF-I axis, GH insensitivity
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